Protein Details: P2X purinoceptor 4a

Protein ID

ICDB_Pro_0132

Protein Name

P2X purinoceptor 4a

Gene Name

p2rx4a

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

389 amino acids

AlphaFoldDB

AF-F8W463-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and calcium (By similarity). CTP; but not GTP or UTP; functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP; it plays multiple role in immunity and central nervous system physiology (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity).

Sequence

MSESVGCCDSVSQCFFDYYTSKILIIRSKKVGTLNRFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADYIIPPQEDGSFFVLTNMIITTNQTQSKCAENPTPASTCTSHRDCKRGFNDARGDGVRTGRCVSYSASVKTCEVLSWCPLEKIVDPPNPPLLADAENFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRKTDPDCPIFRLGDIVGEAEEDFQIMAVHGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVAPGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNIIPTLLNMGAGLALLGLVNVICDWIVLTFMKRKQHYKEQKYTYVDDFGLLHNEDK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 70; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 70; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"; BINDING 72; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 72; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"; BINDING 143; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"; BINDING 189; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 189; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"; BINDING 191; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 296; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 296; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"; BINDING 298; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 298; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"; BINDING 316; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:22535247; ECO:0007744|PDB:4DW1"; BINDING 316; /ligand="CTP"; /ligand_id="ChEBI:CHEBI:37563"; /evidence="ECO:0000269|PubMed:28332633; ECO:0007744|PDB:5WZY"

Disease

Location

DOI ID

10.1016/s0006-291x(02)00760-x; 10.1038/nature12111; 10.1038/nature08198; 10.1038/nature11010; 10.1038/srep45208

RefSeq

NP_705939.1